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The use of CBD in the treatment of Endometriosis!

Endometriosis is a gynecological disease that affects between 10% and 15% of women of reproductive age around the world.

What is Endometriosis?

Endometriosis is a gynecological disease that affects the endometrium of the female reproductive system. It is characterized by the creation of tissue/mucosa inside the uterus, outside the uterine cavity, that is, in other organs of the pelvis: fallopian tubes, ovaries, intestines and bladder. This tissue becomes thicker over time, causing pain and discomfort.

The main symptoms of this pathology are pain and infertility, however there are other symptoms associated with this disease, such as: menstrual cramps, premenstrual pain, pain during sexual intercourse, chronic fatigue and exhaustion, among others.

Endometriosis pain can manifest itself in the form of intense menstrual cramps, pelvic/abdominal pain during sexual intercourse, pain in the intestines during menstruation, or a combination of these symptoms. Diagnosis can be difficult and treatment options are limited.

In recent years, several scientific studies have been carried out in order to discover a treatment that can cure or alleviate the pain caused by this condition. During these studies, it was discovered that patients suffering from endometriosis have a decrease in cannabinoid receptors, which causes an imbalance in the body, making it impossible for patients to lead a normal life. This led to a more in-depth study into how cannabis can be used to treat endometriosis, and the results were quite positive.

People around the world use cannabis-based products to treat endometriosis, menstrual cramps, and other gynecological complications. In recent years, THC and CBD have been shown to be effective in a variety of therapies and are relatively free of side effects.

How can CBD be used to treat Endometriosis?

Several studies have shown that the proper functioning of the endocannabinoid system is essential for a better quality of life and also for the proper functioning of the reproductive system.

Research shows that cannabinoids can treat endometriosis in a number of ways, including:

  • Stop cell proliferation
  • Prevent cell migration
  • Inhibit vascularization of the lesion (blood vessels)
  • Inhibit the innervation of the lesion (nerves)
  • Blocking synthesis of inflammatory prostaglandins
  • Modulate the immune response
  • Desensitizing nerves that transmit pain

Imbalances in the endocannabinoid system are often associated with reproductive complications and diseases – including endometriosis. Research suggests that using cannabinoids under medical supervision can make a huge difference in the health of the reproductive system and consequently in a woman’s well-being.

Cell multiplication and its relationship with Cannabinoids

Our bodies have mechanisms that prevent the growth of abnormal cells and destroy them (apoptosis) before they become a problem. Unfortunately, apoptosis appears to be impaired in people suffering from endometriosis and similar disorders.

The endocannabinoid system is involved in apoptosis and the arrest of cell growth. Perhaps the most famous application of these properties is in cancer treatments. When certain cannabinoid receptors are activated (either by the body’s own endocannabinoids or by plant-based cannabinoids), they can stop cancer cells from multiplying.

Similar research has shown that activation of these receptors inhibits the proliferation of endometriotic tissue in mice.

CBD blocks the activation of the GPR18 receptor, which can prevent endometrial cell migration. There is also evidence that THC causes cell migration by activating this receptor. For this reason, it may be advisable to neutralize THC for pain relief with CBD in the treatment of endometriosis. Endometrial cells multiply, like cancer, and there is also evidence that cannabinoids can also prevent the proliferation of these cells.

The properties of CBD have contributed to combating the symptoms of endometriosis, contributing to a better clinical picture and increasing the quality of life of patients. It is recommended that treatment be carried out under medical supervision.

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